Cosmetics

Instantly observe the effects of products on blood flow and microcirculation in the skin for early signs of irritation or vasodilation.

Breast reconstruction

Blood perfusion imaging helps determine best flap and identify flap ischemia early.

Vascular surgery

Assess the immediate effects of surgical interventions on blood supply during procedures without contact or invasiveness.

Drug testing

Assess the impact of injected or transdermally delivered drugs without impacting the process.

Raynaud’s Phenomenon

Response to cooling provocation provides insight into severity and can help Distinguish RP and vascular occlusion.

Cortical spreading

Identify potential therapeutic targets and strategies to mitigate the adverse effects of cortical spreading that underlies TBI, migraines, and stroke.

Dermatology

The noninvasive and non-contact nature of PeriCam PSI make it an ideal tool for dermatology studies where blood flow in the skin is a significant parameter.

Diabetic foot

Early detection of complications in diabetic foot are crucial to prevent severe outcomes and save limbs.

Peripheral artery disease — PAD

Peripheral artery disease (PAD) affects over 113 million people globally, contributing to pain, disability, and, in severe cases, amputation. Early detection and accurate monitoring are critical for managing this chronic condition.

Hyperbaric oxygen therapy — HBOT

Hyperbaric oxygen therapy (HBOT) is used to treat a variety of conditions including decompression sickness, non-healing wounds, diabetic foot ulcers, burns, and compromised skin grafts.

Clinical exams

Our solutions support a comprehensive range of established clinical exams, delivering robust insights into macro- and microcirculatory function in a noninvasive way.

Skin perfusion pressure — SPP

SPP is a noninvasive method that leverages laser Doppler to measure blood perfusion in the microcirculation. It is primarily used in clinical (and clinical research) settings to assess wound healing potential — especially in patients with chronic conditions such as diabetic foot.

Transcutaneous oxygen — TcpO2

TcpO2 is a noninvasive method that leverages Clark-type electrodes to measure microcirculation by measuring the local pressure of oxygen released through the skin from the capillaries.

Pulse volume recording — PVR

Pulse volume recording (PVR) is a noninvasive method for evaluating blood flow in peripheral arteries based on air plethysmography.

Segmental limb pressure

Segmental limb pressure measurement is a noninvasive macrocirculation exam for evaluating blood perfusion in the limbs. It helps detect blockages or narrowing, making it invaluable for assessing peripheral artery disease (PAD) and end-stage PAD — chronic limb-threatening ischemia (CLTI).

Toe pressure and TBI

Toe pressure and TBI are noninvasive macrocirculation measurements for evaluating blood perfusion in the toes, providing critical insight into vascular health. Toe pressure measurements are useful in wound healing, detecting and managing peripheral artery disease (PAD) and chronic limb-threatening ischemia (CLTI) — especially when ankle pressure may be unreliable due to noncompressible arteries.

Ankle pressure and ABI

Ankle pressure and ankle-brachial index (ABI) are noninvasive macrocirculation measurements for evaluating blood perfusion in the ankles, providing critical insight into vascular health. Ankle pressure measurements are the gold standard for assessing peripheral artery disease (PAD) in people without diabetes.

Finger pressure

Finger pressure or digit-brachial index (DBI) is a noninvasive macrocirculation measurement.

Clinical research protocols

Built on advanced signal processing and laser Doppler technology, our solutions provide comprehensive insights into macro- and microcirculation. They can be used in a range of clinical research applications, including dermatology, endothelial dysfunction, and exercise physiology. Our technologies are designed to facilitate data collection and generate robust insights that help clinical researchers deliver data-driven findings.

Preclinical research

Preclinical researchers often face data collection challenges, like accuracy, repeatability, the need to translate data to clinical applications, and measurement tools that inadvertently introduce artifacts or stress responses in the models.

Middle cerebral artery occlusion (MCAO)

Middle cerebral artery occlusion (MCAO) is a widely used preclinical model for studying ischemic stroke.

CAM assay

The CAM assay is a versatile animal model for studying tumor formation, angiogenesis, and metastasis.

Hindlimb ischemia

Murine hindlimb ischemia is an important model for studying peripheral artery disease (PAD) and developing new therapies for it.

Cutaneous wound healing

To support the metabolic needs of tissue repair during wound healing, the formation of angiogenic capillaries and their organization into microvascular networks is essential.

Neo­vascularization and angiogenesis

Neovascularization and angiogenesis are crucial fields of study because these processes play a significant role in various physiological and pathological conditions.

Cerebral blood flow monitoring

Cerebral blood flow monitoring leverages blood perfusion to understand and assess brain function.

Wound healing

Wound healing can be complex and unpredictable. Stakes are high when healing slows or stalls and every wound presents unique challenges. While foundational methods like visual inspections and touch tests like capillary refill are part of everyday practice, not all wounds respond the same.

Subcutaneous tumor model

The subcutaneous tumor model is a popular assessment system for in vivo evaluation of cancer medicine candidates. This model often uses immunodeficient animal strains, where cultured cancer cells are implanted subcutaneously, taking about two weeks to produce a solid tumor. 

Clinical and clinical research

Microcirculation is crucial for delivering oxygen and nutrients to tissues and removing waste products. This fine-scale blood flow reflects underlying vascular health and is increasingly recognized as a sensitive marker of systemic diseases, including diabetes and peripheral artery disease (PAD).