Probes
A probe for every need
The high-quality Perimed laser Doppler probes allow the study of microcirculation in almost any organ or tissue. All probes are designed for PeriFlux 6000.
Please contact Perimed for probes compatible with older PeriFlux laser Doppler models.
We offer a wide selection of probes as well as different types of disposable microtips for long-term implantation. All probes use a silica fiber with a core diameter of 0.125 mm. The probes are reinforced with Kevlar® for increased strength. Probes are available with several fiber separations 0.15mm, 0.25mm, and 0.55mm with a cable length of 2.80m. Probes and microtips can be disinfected.
SKIN PROBES
PROBE 404-NI noninvasive angled probe
Multi-purpose, low-profile probe with one returning fiber. This probe is designed to take noninvasive laser Doppler measurements of blood perfusion on skin that is intact. It is ideal for SPP measurements. The probe can be attached to the skin with a PF 105-3 double-sided tape strip.
PROBE 407 small straight probe
Multi-purpose probe for fitting into different small probe holders for different applications. The soft, flexible design of the fiber line reduces the influence of artifacts from moving subjects. PROBE 407 can be used on other tissues in certain applications. Probe holders: All PH 07-X Probe Holder
Skin Probes with Heating Capability
PROBE 457 thermostatic small-angled probe
A combined laser Doppler and thermostatic probe for simultaneous blood perfusion measurement and local heat provocation. Double-sided tapes are used for fixation. The probe is watertight and can be kept in water for several hours.
INVASIVE PROBES
PROBE 411 needle probe for micromanipulator
For acute invasive measurements. The support is designed to fit into a micromanipulator or laboratory stand for exact positioning. The tip is thin (0.45 mm) for easy penetration of tissue such as animal brain.
Tissue: Invasively in most organs and tissues
PROBE 407 small straight probe
Multi-purpose probe for fitting into different small probe holders for different applications. The soft, flexible design of the fiber line reduces the influence of artifacts from moving subjects. PROBE 407 can be used on other tissues in certain applications. Probe holders: All PH 07-X Probe Holder
PROBE 418-1 master probe*
Not for human use. For animal research only.
Can easily be connected to/disconnected from a microtip. Microtips are useful for invasive measurements, for example, in muscle, and can be inserted into tissue through a 22 G/0.6 I.D. cannula. For mouse skulls, the microtips should be glued to the surface. Please contact Perimed for “Instructions for Use”.
Microtips: MT B500-0L120, MT B500-0L240
Tissue: Invasive measurements in soft tissue or on mouse skull during MCA occlusion.
CONSUMABLES FOR PROBES
Probe holders and fixation tape
Perimed offers a wide range of probe holders for various probes and purposes. Probes and probe holders are usually fixed to the skin using double-sided tape and remain fixed to the skin only for several hours.
Perimed double-sided tapes are medical grade. The materials used have been tested over many years and are assessed and documented according to ISO 10993-1 guidance and principles. The use of probes, probe holders, and sensors has been shown to have no adverse effects on the skin.
PF 1001 motility standard refill
Calibrating the laser Doppler probes with our motility standard (PF 1001) before use is essential. The motility standard consists of a colloidal suspension of polystyrene particles.
The motility standard should be replaced annually due to the possibility of contamination during regular use.
Microtips
Implantable microtips (single-fiber probes of 120 mm or 240 mm in length) can be sutured or glued in place using a medical-grade cyanoacrylate adhesive. Note that this type of adhesive may cause local tissue damage. The adhesive can usually be loosened with acetone or a proprietary adhesive remover. Alternatively, the probe can be fitted into a micromanipulator which allows the probe and microtip to be positioned in contact with the tissue in a controlled manner.
| Part number | Product name |
|---|---|
| 91-00124 | MT B500-0L120 Straight Microtip (5 pcs) |
| 91-00123 | MT B500-0L240 Straight Microtip (5 pcs) |
STROKE MODEL KIT
Stroke Model monitor for mice and rats
The Stroke Model System is used for simple detection of whether a stroke has been successfully induced in mice and/or rats. Successful middle cerebral artery occlusion (MCAO) is confirmed by real-time monitoring of a ~70% decrease in regional cerebral blood flow.
Specialized kits for rats and mice
For application on mice, we recommend Master Probe 418 equipped with a microtip. The microtip is attached directly to the skull using the glue + accelerator provided in Stroke Model Kit 418. Microtips are available in 120 mm and 240 mm.
For rats, we recommend PROBE 407 which is attached to the skull with probe holder PH 07 using Stroke Model Kit 407.
* To comply with the European Medical Device Regulations for Class 1 devices, this device has been discontinued for human use in Europe since May 25, 2020. After this date, this product is no longer CE-marked and cannot be sold for human use. Note, this is only for Europe and not for the rest of the world. Devices purchased before May 25, 2020, can still be used for human use on the European market.
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